Dr Dave, you've talked a lot about DHEA and Co Q 10 lately. I noticed you have
L-Carnitene in Regenerizer too. What is its purpose? Harry Blechler,Baton Rouge
LA.
Frankly Harry l-Carnitene is just as important as the other compounds In
Regenerizer. The main reason being its primary role in energy generation.
Without getting into too much detail, Carnitene is essential for the burning of
fats. It is part of an enzyme complex that shuttles fats preferentially into the
powerhouses of the cells, the mitochondria.
If you've read my previous emails, you know that as we age, some of these enzymes
and the compounds that make them up start to drop off.
This drop off is in many peoples' opinion one of the main reasons we age.
The mitochondria power the entire cell and without them all of the functions that
support human life are threatened immediately.
Persons born with mitochondrial defects often die in early childhood.
There is a lot of research indicating that a significant number of Type 2
diabetics develop the disease in part because of defects in mitochondrial DNA
which comes exclusively from their mother.
Couple that with a lousy diet high in sugars and Omega 6 fatty acids and a drop
off in the mitochondria's ability to neutralize the free radicals it naturally
produces and you have the makings of many different diseases depending on where
the problem arises.
Drs. Hagen and Ames at the Proceedings of the National Academy of Sciences
presented data that showed that L Carnitene reversed the mitochondrial changes
of aging in elderly rats, prolonging their lives, and more importantly got them
behaving like their junior counterparts.
Human studies of aging have proven impossible to do for various ethical moral,
and of course time reasons. Which group would you want to be in the placebo
(fake pill) study, or the one that got the real stuff. Also as of yet no one is
willing to follow a group of individuals for their entire lives. The Framingham
Heart Study (the one which shows that HDL is as important if not more important
than LDL) comes closest at this point in time.
In humans however L Carnitene seems to reduce vascular dysfunction which is in my
opinion one of the main causes of vascular problems including heart disease, and
stroke as well as diabetes.
When given to people with clogged blood vessels and limited walking distance
thereof, they were able to go longer and harder than before.
Those of you who read my email on irrefutable proof that my supplements can help
athletes (several weeks ago) know that it has been shown to be effective in
improving athletic performance also. Below is the most recent article that
supports this.
This particular study is very new and reinforces what I said in earlier emails.
L Carnitene reduces lactate production, increases maximal oxygen consumption,
buffers against free radicals, speeds recovery from training, improves immune
cell function and preferentially shifts cells towards fat burning. Need I say
more??!!
1: Nutrition. 2004 Jul-Aug;20(7-8):709-15.
Supplementation of l-carnitine in athletes: does it make sense?
Karlic H, Lohninger A.
Ludwig Boltzmann Institute for Leukemia Research and Hematology, Vienna,
Austria.
Studies in athletes have shown that carnitine supplementation may foster
exercise performance. As reported in the majority of studies, an increase in
maximal oxygen consumption and a lowering of the respiratory quotient indicate
that dietary carnitine has the potential to stimulate lipid metabolism.
Treatment with l-carnitine also has been shown to induce a significant
postexercise decrease in plasma lactate, which is formed and used continuously
under fully aerobic conditions. Data from preliminary studies have indicated
that l-carnitine supplementation can attenuate the deleterious effects of
hypoxic training and speed up recovery from exercise stress. Recent data have
indicated that l-carnitine plays a decisive role in the prevention of cellular
damage and favorably affects recovery from exercise stress. Uptake of
l-carnitine by blood cells may induce at least three mechanisms: 1) stimulation
of hematopoiesis, 2) a dose-dependent inhibition of collagen-induced platelet
aggregation, and 3) the prevention of programmed cell death in immune cells. As
recently shown, carnitine has direct effects in regulation of gene expression
(i.e., carnitine-acyltransferases) and may also exert effects via modulating
intracellular fatty acid concentration. Thus there is evidence for a beneficial
effect of l-carnitine supplementation in training, competition, and recovery
from strenuous exercise and in regenerative athletics.
The following study shows the benefit of L Carnitine in people with leg pain from
poor circulation.
: J Am Coll Cardiol. 1995 Nov 15;26(6):1411-6.
Propionyl-L-carnitine in intermittent claudication: double-blind,
placebo-controlled, dose titration, multicenter study.
Brevetti G, Perna S, Sabba C, Martone VD, Condorelli M.
Department of Medicine, University Federico II, Naples, Italy.
OBJECTIVES: The aim of this double-blind, placebo-controlled, dose titration,
multicenter trial was to assess the efficacy and safety of propionyl-carnitine
in intermittent claudication. BACKGROUND: Human and animal studies indicate that
propionyl-L-carnitine increases carnitine content and improves energy metabolism
in the ischemic skeletal muscle. METHODS: After a 2-week preliminary period to
assess maximal walking distance, 245 patients were randomly assigned to receive
propionyl-L-carnitine (n = 118) or placebo (n = 127). The initial oral dose of
500 mg twice daily was increased at 2-month intervals to 2 g/day and then to 3
g/day in patients showing improvement in treadmill performance < 30% over
baseline. Efficacy analysis was conducted for the 214 patients who completed the
24 weeks of treatment by comparing the effect of placebo and
propionyl-L-carnitine on day 180. RESULTS: Analysis of variance showed a
significant improvement of 73 +/- 9% (mean +/- SE) in maximal walking distance
with propionyl-L-carnitine (n = 99) compared with 46 +/- 6% for placebo (n =
115, p = 0.03). For distance walked at onset of claudication,
propionyl-L-carnitine showed about double the improvement of placebo; however,
the difference was not statistically significant. There were no changes in
electrocardiographic and routine biochemical and hematologic tests that would
indicate an adverse effect of propionyl-L-carnitine. Adverse events requiring
drug discontinuation (11 in the propionyl-L-carnitine group, 3 in the placebo
group) were unrelated to study medication. The dose titration design of the
study also provided information on the dose-response relation. Slightly less
than 67% of patients were expected to improve their maximal walking distance by
at least 30%, assuming 2 g/day of propionyl-L-carnitine (95% confidence interval
0.51 to 0.70). The response rate during the entire titration course was
significantly in favor of propionyl-L-carnitine compared with placebo.
CONCLUSIONS: Although the precise mode of therapeutic action requires
clarification, propionyl-L-carnitine, at a dose of 1 to 2 g/day, appears to be
effective and well tolerated, with minimal adverse effects.
Publication Types:
Clinical Trial
Multicenter Study
Randomized Controlled Trial
PMID: 7594063 [PubMed - indexed for MEDLINE]
So in a nutshell 1) protection from aging in the cell's powerhouse, the
mitochondria,2) Improved use of fat as a fuel 3) Improved athletic performance,4)
improvements in blood flow, make this compound an essential ingredient in
Regenerizer's ability to potentially reduce the aging process, improve
performance both athletic and sexual and generate more energy naturally by
burning fat!
Best,
Dave Woynarowski, M.D., CPT
The Nation's #1 Anti-Aging Physician
P.S. For the worlds best anti-aging supplements including Dr Dave's Best
Pharmaceutical Grade Fish Oil go here and order now.
Don't delay; you are not getting any younger, YET!
