Heart attack or stroke - pick your poison Tuesday, May 26, 2009
I have recently covered some in depth mechanisms by which Fish Oil prevents heart attacks, right down to the level of genetic expression.
Interestingly enough the mechanisms by which Fish oil prevents stroke are, "The same only different!" to quote Cheech Marin in 'Up in Smoke'.
Stroke, as it turns out, can be simplified by an understanding of why it happens.
Just like heart attack, stroke, or as it is now often referred to, "brain attack", is caused by an interruption of blood flow to some part or parts of the brain.
Much like the heart, parts of the brain then die. As a matter of fact the heart actually has a lot more resilience to low oxygen levels than the brain.
The traditional value is three minutes of oxygen loss leads to dead brain cells.
Lately a fascinating fact has become apparent. Brain cells do have some capacity to regenerate, and the brain can "grow new" cells if the proper nutrients and growth factors are supplied. It should come as no surprise that Fish oil and Co Q10 are among them.
There is also fascinating research with melatonin and pregnenolone. As more facts become available on this, I'll keep you posted.
Back to the brain. By far and away the majority of strokes are called "ischemic", which means a blood vessel blocked. There is, however, another fairly common subtype called embolic. This happens when the heart is beating irregularly and flicks off a clot that lands "downstream" in the brain.
It can also happen when a piece of cholesterol breaks off a major artery and floats into the brain as well.
Many of you already have figured out how Fish oil may prevent stroke based on the same mechanisms that it prevents heart disease (remember, the FDA doesn't want me using prevent!!).
But there is a little difference between these common Ischemic strokes and heart attacks which are also caused by the same Ischemic mechanism.
If you look at all the progress that has been made at preventing heart disease and strokes, there is something that becomes apparent. Most of the stroke prevention seems to have come from the lowering of the nation's blood pressure. There seems to be almost a 1 to 1 correlation with blood pressure lowering and the reduction of stroke.
Not so with heart disease. If you look at how much improvement in heart attack rate you see with what you'd EXPECT to see with lower blood pressure numbers, heart disease only goes down about 25% of what is expected.
Bottom line: Fish oil can lower the incidence of both according to studies but Fish oil's blood pressure-lowering effect seems to be much more important in stroke prevention...
Other than that the same mechanisms apply to stroke and heart disease:
1) Improvements in the overall inflammatory state of the body
2) Decreased platelet stickiness, improving blood flow into "tight spaces"
3) Plaque stabilization
4) Decreased smooth muscle proliferation in the plaque, again, right down to the genetic expression of these cells growth
5) Improvements in local Nitric Oxide levels, again, from the affect of Fish oil in the genetic expression of the cell
6) Improved recovery and healing of the cells if an ischemic event occurs
Again, this email represents the conglomeration of a bunch of studies I reviewed, not just one study. No drug company was involved in supporting these studies unlike some of the wannabe Omega 3 fatty acids out there.
If you look at it objectively or subjectively you will come to this conclusion: Fish oil in higher doses than is recommended by traditional health organizations will change the course of human health.
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