Pharmaceutical Grade Fish Oil and anti-aging supplements articles - Fish Oil and Cartilage Health and the case of the Fish Oil Psychic...

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Fish Oil and Cartilage Health and the case of the Fish Oil Psychic...

Dear Friend,

You folks have heard me say many times that Fish Oil is good for arthritis. There are many studies out that show benefit in Rheumatoid and Degenerative arthritis.

While I was writing yesterdays email about Plantar Faciitis, it occurred to me I should address the issue of joint health.

I have a lot of athletes in my anti-aging practice, some of the super star calibre. A few of them are world class runners and have emailed me to remind me about how fish oil has helped their joints overall.

Many of them and many many of my "regular patients" to are interested in ways of PREVENTING joint damage, especially those with arthritis in their family.

Once again I have to invoke the FDA warnings that what I am about to say does not carry their seal of approval. But try telling that to the many many patients who are on my fish Oil and love it because their aches and pains are far less, and in some cases gone.

Last week I had a patient. John G who is in his 60's come in. John is not a wealthy man, but like most of us he does not mind paying for something that works. John had been on my Fish Oil for several months and, "Just felt better" when he was on it. When pressed there were 4 things he noticed: 1) he noticed an annoying rash that no one had any cure for prior to me had disappeared. 2) He noticed that after 3 or 4 months on it his memory had improved greatly.3) He noticed his joint aches which had not really responded to an arthritis drug called Celebrex tm had all but disappeared.

One of John's friends who happened to be an aficionado of sorts about natural and alternative therapies had convinced John that he was paying too much for my product. She told him that "It all comes from the same place anyway" and proceeded to tell him all sorts of things that she thought about my product, without even having tried it herself.

My response was that he should definitely follow her advice because, she was clairvoyant. She knew about everything without ever having tried it or investigating it further. She had spoken and John had believed. I suggested he also consult her for help in predicting the stock market and that the government could use her help in national defense.

John confessed that he was a little bit miffed at me. He told me that I had taken great care of him for 15 years now and never steered him wrong.

All of this changed when he tried the brand his mystic friend had suggested and it didn't work!!

Worse, his cholesterol and triglycerides which were the original reason I had put him on the product soared up well past their original levels.

John was a little sheepish when he told me all of this stating that 15 years of good care should have told him something. He wound up buying a case.

I told him not to worry My family (my dad and I) had cared for his family (his parents and himself ) for several decades when you added it all up and this should not interfere with that relationship.

I must confess I am a little less tolerant with people I don't know as well.

So, on to the science behind Fish Oil's saving effect on the joints.

When we are done her you will see that once again big pharmacy has reinvented Mother Nature's wheel but by now that should not surprise you.

Cartilage is the lining of the joint. Understand that bones do not directly rub on bones at least not in a healthy joint!

As a matter of fact "bone on bone" usually means you are on an orthopedic surgeons schedule for a joint replacement, or about to be.

There is also a fluid that helps the bone-cartilage complex slide along over each other. We call this synovial fluid. This fluid needs to be there for smooth operation of the joint. This fluid is made by healthy cartilage cells and is either not made or made in less amounts than it needs to be if those cartilage cells are sick.

Let me take this opportunity to apologize to my orthopedic surgeon and Rheumatologic members who are reading this. I am of course as usual simplifying this!!

Anyway damage to these chondrocytes starts like many other disease process in the body, with inflammation.

The specific chemicals involved have names like IL 1 (interleukin 1) and TNF alpha (tumor necrosis factor alpha) and COX 2 (cyclooxegenase 2).

These are all mediators of inflammation in the joint (and the rest of the body). When they are present in high numbers a destructive process is set into motion that ultimately leads to less synovial fluid, and damage to the cartilage of the joint.

Interestingly there is a TNF alpha inhibitor out there that is used in severe cases of Rheumatoid Arthritis called Enbrel tm . I have used it in some of my sever cases of Rheumatoid Arthritis, and it does work. Trouble is there are some very nasty side effects, and it costs about $12,000 a year. Couple this with the fact that not all insurances pa for it, and you have a typical statement about "Modern medicine".

Now I will be the first person to admit that this drug ahs helped some of my people, but by now you know," an ounce of prevention is worth a pound of cure".

Or as my patient John G found out $60/month for Fish Oil is worth more to him that $12,000 a year when the cat is already out of the bag!

There is something else that fish Oil does that no prescription drug has been able to match yet.

Fish Oil actually works at the genetic level of those cartilage cells (chondrocytes) and affects the transcription of their genetic material to positively improve their response to inflammation and the production of the synovial fluid we spoke about.

Now I cannot come out and say that if we have the type of Omega 3 fatty acid intake (fish Oil) we should that we could prevent arthritis altogether, but I can believe that it would go a long way towards achieving this end.

We are all going to live a lot longer than our ancestors did as a people. The difference between a vibrant active person and a cripple starts RIGHT NOW!!

The cumulative damage associated with arthritis is happening inside our joints LONG BEFORE we get to the stage where there is pain.

By now I hope you see the recurring theme here. The damage that becomes diabetes starts long before the blood sugar goes up. The damage that becomes a clogged blood vessel in the heart or the brain starts long before the heart attack or stroke, and so on and so on.

Fifty years ago a pathologist who was doing autopsies on soldiers killed in the Korean War noticed that atherosclerosis had begun in these unfortunate soldiers, the youngest of whom was only 17!!

When patients come to me concerned about preventing arthritis I tell them the same thing I just told all of you. Start Fish Oil now and you will have done what in my opinion is the only thing that has any proof to it to influence the course and prevention of arthritis.

By the way this includes Chondroitin and Glucosamine that seem to have pain killing effects, but have not yet been proven to reduce joint damage or improve recovery.

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References:

1: Proc Nutr Soc. 2002 Aug;61(3):381-9.

Effects of n-3 fatty acids on cartilage metabolism.

Curtis CL, Rees SG, Cramp J, Flannery CR, Hughes CE, Little CB, Williams R, Wilson C, Dent CM, Harwood JL, Caterson B.

Cardiff School of Biosciences, Cardiff University, UK.

Although the clinical benefits of dietary supplementation with n-3 polyunsaturated fatty acids (PUFA) has been recognised for a number of years, the molecular mechanisms by which particular PUFA affect metabolism of cells within the synovial joint tissues are not understood. This study set out to investigate how n-3 PUFA and other classes of fatty acids affect both degradative and inflammatory aspects of metabolism of articular cartilage chondrocytes using an in vitro model of cartilage degradation. Using well-established culture models, cartilage explants from normal bovine and human osteoarthritic cartilage were supplemented with either n-3 or n-6 PUFA, and cultures were subsequently treated with interleukin 1 to initiate catabolic processes that mimic cartilage degradation in arthritis. Results show that supplementation specifically with n-3 PUFA, but not n-6 PUFA, causes a decrease in both degradative and inflammatory aspects of chondrocyte metabolism, whilst having no effect on the normal tissue homeostasis. Collectively, our data provide evidence supporting dietary supplementation of n-3 PUFA, which in turn may have a beneficial effect of slowing and reducing inflammation in the pathogenesis of degenerative joint diseases in man.

PMID: 12230798 [PubMed - indexed for MEDLINE]

1: J Biol Chem. 2000 Jan 14;275(2):721-4.

n-3 fatty acids specifically modulate catabolic factors involved in articular cartilage degradation.

Curtis CL, Hughes CE, Flannery CR, Little CB, Harwood JL, Caterson B.

Connective Tissue Biology Laboratories, Cardiff School of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3US, United Kingdom.

This study describes specific molecular mechanisms by which supplementation with n-3 fatty acids (i.e. those present in fish oils) can modulate the expression and activity of degradative and inflammatory factors that cause cartilage destruction during arthritis. Our data show that incorporation of n-3 fatty acids (but not other polyunsaturated or saturated fatty acids) into articular cartilage chondrocyte membranes results in a dose-dependent reduction in: (i) the expression and activity of proteoglycan degrading enzymes (aggrecanases) and (ii) the expression of inflammation-inducible cytokines (interleukin (IL)-1alpha and tumor necrosis factor (TNF)-alpha) and cyclooxygenase (COX-2), but not the constitutively expressed cyclooxygenase COX-1. These findings provide evidence that n-3 fatty acid supplementation can specifically affect regulatory mechanisms involved in chondrocyte gene transcription and thus further advocate a beneficial role for dietary fish oil supplementation in alleviation of several of the physiological parameters that cause and propogate arthritic disease.

PMID: 10625599 [PubMed - indexed for MEDLINE]

Please note that unlike some world experts on alternative medicine, I do not quote the publisher of my newsletter, USA Today or the National Enquirer to verify my claims!!

Dave Woynarowski, M.D., CPT
The Nation's #1 Anti-Aging Physician

P.S. For the worlds best anti-aging supplements including Dr Dave's Best Pharmaceutical Grade Fish Oil go here and order now. Don't delay; you are not getting any younger, YET!