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Fish Oil and Depression Part 2

Dear Friend,

Ok folks! Now let's examine why fish Oil makes a natural choice to use for depression and other mood disorders.

For review, yesterday we talked about how a large part of the brain especially the membranes of the nerves there are made up of Essential

We examined how investigators have found roles for Fish Oil in various Brain related disorders including Alzheimer's Disease, ADD, autism, schizophrenia, hostility, anxiety, borderline, and bipolar disorders in this and other emails!

We discussed the Omega 6 to Omega 3 ratio which the Journal of the American college of Nutrition suggests should be 1:1 ( J. AM. Coll. Nutr. 1999;18:487-489 Simopoulos). It is now 20:1 or above thus high lighting the need for HIGH DOSE Fish Oil to correct it!

So now let's take a simplistic look at how Fish Oil may enhance the treatment of Major and minor depression from a biochemical point of view.

If you want to look at brain function in a depressed patient vs. those of a normal non- depressed person you can use several imaging studies including MRI and PET scanning. You can also use chemical uptake and turn around studies that use sugar and other biochemical markers of cellular activity and respiration.

If you look at the very specific places in the brain where depression causes biochemical abnormalities (Limbic system, Nucleus accumens, and certain other areas of the frontal lobe), you find that certain chemicals are either lacking in absolute amount, or not released properly.

Once you treat with Fish Oil, those biochemical abnormalities often reverse.

Additionally several areas of the brain show decreased blood flow and decreased use of sugar, both indicators of low function.

Fish Oil usage reverses those abnormalities as well in studies.

Other studies have showed that in depression actual areas of the brain atrophy or shrink leading to the loss of nervous tissue. In other words brain cells die!

In the past no one ever thought you could regenerate new brain cells, but this is exactly what Fish Oil promotes.

This is also the probable reason it works in Alzheimer's as well!

High amounts of physical and emotional stress can activate pro-inflammatory chemicals in the brain as well as he body that interfere with the cell's ability to bind vital brain transmitters like dopamine and serotonin ( see yesterdays' email!).

By now you are well versed in knowing how Fish Oil can decrease the amount of inflammation in the body and brain, thus combating the problem of the bad effects of too much Omega 6 or too much stress.

If you look at the nerve cells themselves 2 amazing things become apparent. In addition to needing Fish Oil's component fatty acids to be in their membranes, they actually secrete DHA and bathe themselves in it!

Next if you look at the activity of the nerve cell to signal the next cell in line (ultimately how the brain works!) low omega 3's in the diet reduce this activity (synaptic) by over 40%!

Some of you take DHEA and Phosphotidyl Serine for memory and thinking effects. Fish Oil enhances the endogenous production of these vital neuro-hormonal transmitters.

Low Omega 3 in the diet results in a 35% decrease in the brain's ability to produce Phosphatidyl Serine which has anti-depressant activity of its own!

Omega 3 fatty acids also increase the density and number of serotonin receptors in the frontal cortex. Recall that the SSRI's which stands for Selective Serotonin Reuptake Inhibitors, block the breakdown of serotonin effectively doing the same thing but with tons more side effects.

Another study found that high dose fish oil supplementation(15X greater than the usual dose) blocked the activity of the enzyme that breaks down the key neurotransmitter Dopamine. This enzyme called MAO-B is the target for another effective but potentially deadly class of drugs called MAO inhibitors.

In all studies Fish Oil supplementation was deemed extraordinarily safe. But then why wouldn't it be, Mother Nature put it here for us to use!

One specific case study placed a "Treatment Resistant" patient who had failed all the regular drugs on Fish Oil 4grams a day. Within 1 month there where major subjective and objective improvements in their depression.

Measured chemical parameters improved and the size of the brain actually grew as measured by the MRI! (Br, J, of Psychiatry 200;176:421-428.)

There are several major studies using Omega 3 Fatty Acids in humans. The success rate is around 85% of these studies. Negative trials tended to use DHA alone. This reinforces my earlier statements about not separating these 2 vital components of Fish Oil

One note, researchers discovered that Flaxseed oil had the potential to cause mania, hypomania and other untoward behavioral abnormalities when substituted for Fish Oil in the treatment of depression.

One more reason to avoid Flax Oil!

As far as dosages go, I'd recommend you start on the high side e.g. 6 capsules a day at least, especially if you are suffering from more severe depression.

Fish Oil can also augment the activity of almost every class of anti-depressant drug, so they can be taken together.

Remember depression can be a very serious illness. I personally like the way fish Oil keeps my moods up, my creativity high my memory sharp and my energy roaring (along with Regenerizer and Instant Endurance!).

But then again I am not typically depressed. If you are depressed get your doctors help!

Major Review: Alternative Medicine Review Vol 8 # 4 2003 pp410-425.

Prostaglandins Leukot. E.F.A. 2004 Jul;71 (1) :13-18

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