Supplements For People With Cardiac Conditions

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Sneaking Supplements into the Coronary Care Unit

Dear Friend,

One thing that you have to understand is that Alternative Medicine is not exactly welcome in the hallowed halls of traditional medicine.

As you are aware from recent emails especially the email concerning statin induced cardiomyopathy and Regenerizer's potential for helping sick hearts, adding some complementary supplementation to preexisting treatments may not only be smart, but in some cases life saving.

To this end I have on occasion asked patients and their families to bring in their supplements to the hospital while I was caring for them there.

One situation where I felt this was very helpful and potentially life saving was that of heart attack.

A heart attack usually occurs when blood vessels that supply the heart become clogged with "plaques" which are in my opinion the by products of chronic inflammation in these blood vessels.

I have in past issues referred to this as "coronary angiitis".

Once blood flow slows to a crawl in these arteries, circulating blood products that are normal found in low concentrations accumulate and cause a clot to form stopping blood flow altogether.

The heart which is mostly muscle and highly oxidative (requires oxygen to survive) then begins to die piece by piece.

Another event that is common in this process is that the heart can become irritable and "fibrillate" or beat irregularly which can be fatal.

Recall one of the main effects of fish oil is to prevent this fibrillation and sudden death.

Ironically fish oil is not a supplement that I would normally have people sneak in because it is a blood thinner and they are usually on prescription thinners like heparin and Plavix.

Besides most of the folks that take fish oil don't wind up in the heart attack unit!

I do however Regenerizer with its whopping dose of Co q (200mg) is one supplement I would routinely prescribe in the Coronary Care unit.

Remember I said the heart is a highly "Oxidative" muscle. Meaning it needs lots of oxygen to survive. Cardiac muscle is specialized and like no other muscle found in the body.

It is loaded with "mitochondria" the tiny furnaces that power all cells. There are more mitochondria in heart muscle than anywhere else in the body.

All of the ingredients in Regenerizer are critical to the function of the mitochondria.

Co Q acts like an electrical wire to transfer energy from food oxygen and water into the final universal energy product that the cells use, ATP.

In addition it is able to soak up vast amounts of free radicals generated during this process thus protecting the cells and their components from damage.

L Carnitene shuttles fat into the mitochondria helping to burn it preferentially over other fuels.

DHEA has an almost thyroid like activity on cellular metabolism.

Malic acid is a key intermediate in the energy generation cycle.

What does all this have to do with heart attacks?

Well one of the first things that stops in sick ad dying heart muscle when a person has a heart attack is energy generation. No energy no heart beat. No heart beat, no blood flow. No blood flow and no life!

Another thing that happens is the build up off unbuffered oxygen free radicals. This can further the damage that is already done.

While discussing this very topic with one of the reps from Pfizer the company who makes Lipitor, the rep made a very interesting comment when I told her about using these compounds in heart attack patients.

She said, "I have been to some very high level Cardiology meetings as part of my education. Lately you hear more and more about Co Q in heart disease. I think the thought leaders are already starting o use it."

I look forward to the day when Regenerizer is on the Coronary Care Unit formulary!

So you've heard my experiences, no w what's the evidence?

Mol Cell Biochem. 2003 april;246 (1-2) : 75-82.

This study is amazing because it provides randomized, placebo controlled trial data that supports the use of CoQ in heart attack.

There were 45% fewer coronary events, improved HDL good cholesterol levels and 40% less fatigue in the Co Q treated patients.

Additionally the group that did not get Co q did get cholesterol lowering drugs. So Co Q 's benefits extended beyond "optimal" lipid lowering with statin drugs.

1: Mol Cell Biochem. 2003 Apr;246(1-2):75-82.

Effect of coenzyme Q10 on risk of atherosclerosis in patients with recent myocardial infarction.

Singh RB, Neki NS, Kartikey K, Pella D, Kumar A, Niaz MA, Thakur AS.

Medical Hospital and Research Centre, Moradabad, India. icn@mickyonline.com

In a randomized, double-blind, controlled trial, the effects of oral treatment with coenzyme Q10 (CoQ10, 120 mg/day), a bioenergetic and antioxidant cytoprotective agent, were compared for 1 year, on the risk factors of atherosclerosis, in 73 (CoQ, group A) and 71 (B vitamin group B) patients after acute myocardial infarction (AMI). After 1 year, total cardiac events (24.6 vs. 45.0%, p < 0.02) including non-fatal infarction (13.7 vs. 25.3%, p < 0.05) and cardiac deaths were significantly lower in the intervention group compared to control group. The extent of cardiac disease, elevation in cardiac enzymes, left ventricular enlargement, previous coronary artery disease and elapsed time from symptom onset to infarction at entry to study showed no significant differences between the two groups. Plasma level of vitamin E (32.4 +/- 4.3 vs. 22.1 +/- 3.6 umol/L) and high density lipoprotein cholesterol (1.26 +/- 0.43 vs. 1.12 +/- 0.32 mmol/L) showed significant (p < 0.05) increase whereas thiobarbituric acid reactive substances, malondialdehyde (1.9 + 0.31 vs. 3.1 + 0.32 pmol/L) and diene conjugates showed significant reduction respectively in the CoQ group compared to control group. Approximately half of the patients in each group (n = 36 vs. 31) were receiving lovastatin (10 mg/day) and both groups had a significant reduction in total and low density lipoprotein cholesterol compared to baseline levels. It is possible that treatment with CoQ10 in patients with recent MI may be beneficial in patients with high risk of atherothrombosis, despite optimal lipid lowering therapy during a follow-up of 1 year. Adverse effect of treatments showed that fatigue (40.8 vs. 6.8%, p < 0.01) was more common in the control group than CoQ group.

Publication Types:

The next study published in Molecular Aspects of Medicine showed that when co Q was given early in the heart attack( within 6 hours) there were lower levels of damage by blood markers. More importatnly at the end of 1 year 20% of the group that did not get the Co Q died. Only one of the CoQ group died and that was not from cardiac causes at all!

Do you think I put my heart attack patients on Regenerizer!! Every chance I get!!

1: Mol Aspects Med. 1994;15 Suppl:s143-7.

Coenzyme Q10 and antioxidants in acute myocardial infarction.

Kuklinski B, Weissenbacher E, Fahnrich A.

Klinik fur Innere Medizin (Department of Internal Medicine), Klinikum Sudstadt, Rostock, Germany.

Sixty-one patients admitted with acute myocardial infarction, and a symptom's duration of less than 6 hr were randomized into two groups. Immediately after hospitalisation, members of the verum group (n = 32) received 500 mcg of selenium (as sodium selenite). Thereafter they received a daily dosage of 100 mg coenzyme Q10 (Bio-Quinone) and 100 mcg selenium (Bio-Selenium in the form of 1-seleno-methionine) for a period of one year. The control group (n = 29) were given matching placebo preparations. The groups were comparable as with respect to age, sex and medical treatment. Biochemical parameters showed a reduced concentration of CPK- and ASAT-level in the verum group during the acute phase (although not statistically significant). None of the patients in the verum group (i.e. on antioxidative treatment) showed prolongation of the frequency corrected QT-interval. In the control group, 40% revealed a prolongation of the QT-interval by more than 440 msec (p < 0.001). There were no significant differences, with respect to early complications. During the one-year follow-up period after myocardial infarction, six patients (20%) from the control group died from re-infarction whereas one patient from the verum group suffered a non-cardiac death.

The next study proves a point I made in an earlier email about Regenerizer and statin drugs. Not only does it protect against the muscle and heart damage statins may cause, it may also help reduce the cholesterol levels above and beyond what has already been achieved with the statin. Additionally there was the lower blood sugar tendencies I discussed when talking about Regenerizer and diabetes control.

1: Int J Cardiol. 1999 Jan;68(1):23-9.

Serum concentration of lipoprotein(a) decreases on treatment with hydrosoluble coenzyme Q10 in patients with coronary artery disease: discovery of a new role.

Singh RB, Niaz MA.

Centre of Nutrition, Medical Hospital and Research Centre, Moradabad, India.

OBJECTIVE: To examine the effect of coenzyme Q10 supplementation on serum lipoprotein(a) in patients with acute coronary disease. STUDY DESIGN: Randomized double blind placebo controlled trial. SUBJECTS AND METHODS: Subjects with clinical diagnosis of acute myocardial infarction, unstable angina, angina pectoris (based on WHO criteria) with moderately raised lipoprotein(a) were randomized to either coenzyme Q10 as Q-Gel (60 mg twice daily) (coenzyme Q10 group, n=25) or placebo (placebo group, n=22) for a period of 28 days. RESULTS: Serum lipoprotein(a) showed significant reduction in the coenzyme Q10 group compared with the placebo group (31.0% vs 8.2% P<0.001) with a net reduction of 22.6% attributed to coenzyme Q10. HDL cholesterol showed a significant increase in the intervention group without affecting total cholesterol, LDL cholesterol, and blood glucose showed a significant reduction in the coenzyme Q10 group. Coenzyme Q10 supplementation was also associated with significant reductions in thiobarbituric acid reactive substances, malon/dialdehyde and diene conjugates, indicating an overall decrease in oxidative stress. CONCLUSION: Supplementation with hydrosoluble coenzyme Q10 (Q-Gel) decreases lipoprotein(a) concentration in patients with acute coronary disease.

Some of you may be wondering why not just take Co Q 200mg? There are a coupe of reasons... First the other ingredients synergize to boost the effect of the Co Q in Regenerizer.

All of them are bioenergetic compounds meaning they contribute to the cell's ability ( and thus your ability) to make energy efficiently.

Next I priced 200mg of Co Q at the local vitamin store ( a national chain). $59.95 for the Co Q alone, and that my friend was FOOD GRADE not pharmaceutical grade material. By now you know there is no comparison.

One final point about Regenerizer: all of the substances that are part of Regenerizer decline I the cells of many people just with the aging process alone.

I think this raises the likelihood of cardiac and other damage as I mentioned in the statin-cardiomyopathy issue.

To me Regenerizer is another premiere anti-aging compound, containing key ingredients to improve health and actually combat disease, although the FDA doesn't want you to hear that!!

One final Point about my newsletters: yes other "gurus" do read them and copy them both in content and topics. It makes writing their newsletters easier!

But, I want you to notice, I do not quote the Girl Scout Manual, the Wall street Journal, body building magazines ( at least not routinely!) or some other guru's newsletters! I do my own research and use credible medical sources! Before you email me about so and so said this and its different than what you said, please check their sources if they even bother to give them.

If they are using bogus non scientific sources it should not be too hard to figure out how much value to place in what they say.

Additionally wherever possible I quote human studies!

Best,

Dave Woynarowski, M.D., CPT
The Nation's #1 Anti-Aging Physician

P.S. For the worlds best anti-aging supplements including Dr Dave's Best Pharmaceutical Grade Fish Oil go here and order now. Don't delay; you are not getting any younger, YET!