The effects of Nitric Oxide

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Another Brick in the Wall Part 3 JUST SAY N.O.

The effects of Nitric Oxide on Human Health

Dear Friend, The role of Nitric Oxide (N. O.) in health and disease has been well established in just the past year or so.

Like so many other things, use preceded science by over a century.

I always think of this when I hear someone quip that there is "no evidence" to support the use of a supplement for such and such.

Digitalis comes from the foxglove plant and that plant has been used for centuries.

How much evidence was there when Banting And Best first injected insulin into a human?

Actually there was quite a lot... in dogs only Zero in people! Still they moved ahead a introduced a cure for what was a fatal disease.

If the same criteria that we have today were applied to these drugs, they would all still be in clinical trials.

Probably several of them wouldn't be even released today because they could not be patented! Who could patent the foxglove plant?

Answer: maybe Merck or Pfizer could get a "Use" patent.

Thankfully the drug industry was not yet well established.

But let's look at Bayer, still a Giant in the industry.

White willow bark was a remedy for centuries, but then salicylic acid (aspirin) was isolated and the trend toward extracting a single ingredient from what Mother Nature put here for us to use and patenting it began.

Thus an industry was born!

Right now Nitroglycerin is not the most popular N.O. drug. Viagra tm is!

There will be many applications for nitric oxide inhibitors and the like in the near future as the role of this critical naturally occurring chemical is delineated.

I began Parts 1 and 2 of this email by talking about how Instant Endurance can improve Lactic Acid metabolism either by limiting its production (ala Lance Armstrong) and or allowing us to get rid of it faster.

This leads to Improved endurance.

The role of Nitric Oxide is also very important.

Nitric Oxide is a potent vasodilator that is it opens up blood vessels and improves blood flow.

Improved blood flow in exercise does the following.

1) Improves Oxygen and nutrient delivery to the working muscle

2) Clears out waste products, like Lactic Acid faster, also leading to improved performance and endurance.

3) Improves delivery of critical hormones and growth factors such as Testosterone and Growth Hormone (HGH)

4) Prevents the build up of inflammatory chemicals which allows you to go longer and recovery quicker.

In terms of improved health, increasing Nitric Oxide levels reduces:

1) heart attack

2) Stroke

3) Improves blood flow to the genitalia leading to better sexual response.

4) Reduction in any illness that results form decreased blood flow.

Along with Lactic Acid, Nitric Oxide metabolism is another key way that Instant Endurance can work for you to improve all aspects of your physical performance, not to mention disease prevention.

All the Best form the King of Pharmaceutical Grade Fish Oil (which also raises Nitric Oxide levels!), Dr Dave!

References:

1: Life Sci. 2000 Feb 25;66(14):1369-76.

Protein constituent contributes to the hypotensive and vasorelaxant activities of Cordyceps sinensis.

Chiou WF, Chang PC, Chou CJ, Chen CF.

National Research Institute of Chinese Medicine, Taipei, Taiwan, ROC.

Cordyceps sinensis is a herb medicine in China for the treatment of general debility after sickness and for persons of advanced age. In the present study, cordyceps sinensis was extract by phosphate buffer saline (PBS) and dialyzed overnight against PBS using a membrane cut off at 3,500 dalton molecular weight. The resulting macromolecule fraction (defined as CS) was assayed in anesthetized rats for hypotensive effects and in isolated aorta for vasorelaxant effects. Intravenous injection of CS (8,16, 24 and 32 mg/kg, respectively) suppressed significantly the mean arterial pressure (MAP) in a dose-dependent manner. 32 mg/kg of CS induces the maximal hypotensive response with a 58 +/- 4 mm Hg (from 107 +/- 6 to 49 +/- 3 mm Hg) change in MAP and a over 45 min action duration. In aortic rings precontracted with phenylephrine treatment with CS between 0.5 and 500 microg/ml induced dose dependent relaxation. Maximal vasorelaxant response evoked by 150 microg/ml CS was 68.9 +/- 7.3%. Furthermore, CS-induced vasorelaxation is mediated by the endothelium possibly by stimulating the release of the nitric oxide and endothelium-derived hyperpolarizing factor. In conclusion, the present study revealed that presence of a constituent in CS which reduces MAP by relaxing the vascular beds directly. However, the effect may be caused by a single active ingredient or by the combined action of many active agents found in the extract.

PMID: 10755473 [PubMed - indexed for MEDLINE]

2 Toxicol Appl Pharmacol. 2003 Jul 1;190(1):1-8.

Methanol extract of Cordyceps pruinosa inhibits in vitro and in vivo inflammatory mediators by suppressing NF-kappaB activation.

Kim KM, Kwon YG, Chung HT, Yun YG, Pae HO, Han JA, Ha KS, Kim TW, Kim YM.

Department of Molecular and Cellular Biochemistry, School of Medicine, Kangwon National University, Chunchon, Kangwon-Do 200-701, South Korea.

Cordyceps pruinosa has been used in traditional folk medicine to treat numerous diseases. The molecular mechanism of C. pruinosa pharmacological and biochemical actions of macrophages in inflammation has not been clearly elucidated. We examined how the methanol extract of C. pruinosa regulates production of IL-1beta, TNF-alpha, nitric oxide (NO), and prostaglandin E(2) (PGE(2)) in vitro and in vivo. The extract inhibits these inflammatory mediators in LPS-stimulated murine macrophage cell line RAW264.7 and primary macrophages, by suppressing gene expression of IL-1beta, TNF-alpha, inducible nitric oxide synthase, and cyclooxygenase-2. Moreover, the extract suppresses the nuclear transcription factor NF-kappaB activation in LPS-stimulated RAW264.7 cells. Administration of the extract significantly decreases the plasma levels of these inflammatory mediators in LPS-injected mice. These results suggest that the C. pruinosa methanol extract suppresses inflammation through suppression of NF-kappaB-dependent inflammatory gene expression, suggesting that the C. pruinosa extract may be beneficial for treatment of endotoxin shock or sepsis.

PMID: 12831777 [PubMed - indexed for MEDLINE]

3: JOP. 2001 Jan;2(1):16-25.

Association of free radicals and the tissue renin-angiotensin system: prospective effects of Rhodiola, a genus of Chinese herb, on hypoxia-induced pancreatic injury.

Ip SP, Che CT, Leung PS.

School of Chinese Medicine, Department of Physiology, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong.

The renin-angiotensin system has long been recognized as crucial factor in the regulation of the systemic blood pressure and renal electrolyte homeostasis. Numerous studies have demonstrated the presence of a local renin-angiotensin system in a variety of organs. A recent study of the pancreatic renin-angiotensin system showed that chronic hypoxia significantly increased the mRNA expression for angiotensinogen II receptor subtypes AT1b and AT2. The activation of the renin-angiotensin system may play an important role in cellular pathophysiological processes. Angiotensin II enhances the formation of reactive oxygen species via the activation of xanthine oxidase or NAD(P)H oxidase. The reactive oxygen species can cause oxidative damage in the pancreas and other tissues either directly or indirectly via the formation of other radicals such as reactive nitrogen species. Rhodiola therapy may protect hypoxia-induced pancreatic injury in two ways. It prevents hypoxia-induced biological changes by increasing intracellular oxygen diffusion and efficiency of oxygen utilization. Alternatively, it reduces hypoxia-induced oxidative damage by its antioxidant activities.

Publication Types: Review Review, Tutorial

PMID: 11862018 [PubMed - indexed for MEDLINE]

4: Naunyn Schmiedebergs Arch Pharmacol. 2004 May;369(5):473-80. Epub 2004 Apr 17.

Vascular effects of Siberian ginseng (Eleutherococcus senticosus): endothelium-dependent NO- and EDHF-mediated relaxation depending on vessel size.

Kwan CY, Zhang WB, Sim SM, Deyama T, Nishibe S.

HSC-4N40, Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, L8 N 3Z5, Canada. kwancy@univmail.mcmaster.ca

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Best,

Dave Woynarowski, M.D., CPT
The Nation's #1 Anti-Aging Physician

P.S. For the worlds best anti-aging supplements including Dr Dave's Best Pharmaceutical Grade Fish Oil go here and order now. Don't delay; you are not getting any younger, YET!